Early recognition of paroxysmal nocturnal hemoglobinuria (PNH) in a 39-year-old woman with unexplained anemia led to treatment starting before any blood clot, or thrombotic, complications were detected, according to a case report from Portugal. The woman sought emergency care multiple times after several weeks of worsening fatigue and recurrent…
News
Improved access to standard-of-care treatments could significantly improve outcomes for people with paroxysmal nocturnal hemoglobinuria (PNH) living in South India, a study found. The researchers said poor outcomes, including frequent complications, repeated hospitalizations, and increased mortality, were largely driven by greater reliance on supportive care in the region. “Supportive…
People with paroxysmal nocturnal hemoglobinuria (PNH) have abnormalities in infection-fighting immune cells called natural killer (NK) cells, a study showed, shedding light on how this blood cell disorder may dysregulate the immune system. The study, “Role of NK cells in immune escape in patients with classical…
A healthy baby was born after exposure to Ultomiris (ravulizumab-cwvz) during the first trimester of pregnancy in a 25-year-old woman with paroxysmal nocturnal hemoglobinuria (PNH), according to a new case report. The woman was on Ultomiris when she was found to be pregnant. Because little is known about…
In 2025, PNH News delivered timely coverage of the latest research developments and advances in care related to paroxysmal nocturnal hemoglobinuria (PNH). To close the year, we’ve compiled the five most-read stories. As we move into 2026, we remain committed to supporting the PNH community with clear reporting…
A rare case of paroxysmal nocturnal hemoglobinuria (PNH) coexisting with diffuse large B-cell lymphoma (DLBCL), a type of blood cancer, was chronicled in a new report that sought to elucidate some of the challenges that can come with the management of the acquired blood disorder co-occurring with this cancer.
Treatment with PiaSky (crovalimab-akkz) controls hemolysis — the destruction of red blood cells in the body — in nearly all people with paroxysmal nocturnal hemoglobinuria (PNH), according to the results of a pooled analysis of published clinical trials. Further, the data also showed that about two-thirds of individuals…
Empaveli (pegcetacoplan) was safely administered during a woman’s pregnancy to manage hard-to-control paroxysmal nocturnal hemoglobinuria (PNH), according to a recent study. Results showed that Empaveli effectively controlled the mother’s PNH, and the baby was born without complications. There were no detectable signs of the medication in…
Doctors for the first time used PiaSky (crovalimab-akkz) to control paroxysmal nocturnal hemoglobinuria (PNH) in a woman with the autoimmune disease systemic lupus erythematosus (SLE), according to a case study. The study’s authors said the case is the seventh documented instance of PNH occurring in someone with…
A case report highlights the steps necessary to prevent dangerous clots and minimize bleeding when performing a cesarean section on someone who has co-occurring paroxysmal nocturnal hemoglobinuria (PNH) and aplastic anemia, a condition in which the bone marrow fails to produce enough blood cells. Researchers in Greece described the…
Recent Posts
- New study backs approved therapy as a safe, effective treatment for PNH
- Rebuilding self-esteem after a PNH diagnosis
- Soliris helps curb blood clot risk in PNH, but monitoring still needed
- Am I still sick, or have I just forgotten what healthy feels like?
- Switching to Fabhalta boosts hemoglobin, eases fatigue in PNH