Increasing dosing of Empaveli (pegcetacoplan) followed by co-administering Soliris (eculizumab) effectively managed acute red blood cell destruction in a woman with paroxysmal nocturnal hemoglobinuria (PNH), a study shows. The effort underscores how acute red blood cell destruction “requires prompt diagnosis and treatment to avoid potentially…
A pregnant woman with paroxysmal nocturnal hemoglobinuria (PNH) and an inherited blood clotting disorder had a successful and uneventful pregnancy after receiving tailored treatment with Soliris (eculizumab) and anti-clotting therapy. “With the combined expertise of hematologists and obstetricians, comprehensive care can be provided to pregnant women with PNH, minimizing the…
Epysqli (SB12), a biosimilar of Soliris (eculizumab), is as effective as the reference therapy in reducing the need for blood transfusions in patients with paroxysmal nocturnal hemoglobinuria (PNH). That’s according to a post-hoc analysis of the pivotal Phase 3 SB12 study (NCT04058158), whose findings supported Epysqli’s approval in…
A rare case of portal vein thrombosis (PVT) — where a clot blocks blood flow in the portal vein, a major liver blood vessel — in a 49-year-old woman with paroxysmal nocturnal hemoglobinuria (PNH) was detailed in a case report. Transjugular intrahepatic portosystemic shunt (TIPS), a surgical procedure that…
Early mortality in people with paroxysmal nocturnal hemoglobinuria (PNH) is linked to being older and having heart or blood disorders and a history of solid tumors at diagnosis, a Danish study has found. The leading causes of death among patients were infections and associated blood-related diseases, while the approved…
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