News

PNH disease management in the Middle East similar to other regions

The management approach to paroxysmal nocturnal hemoglobinuria (PNH) in the Middle East is generally consistent with that reported in other regions, according to a review of published studies. Across all studies from Saudi Arabia, Kuwait, Egypt, Oman, and Lebanon, anemia and fatigue were common presenting symptoms, with most patients…

Ultomiris as effective as Soliris for PNH: Real-world analysis

Ultomiris (ravulizumab-cwvz) is as effective or better than Soliris (eculizumab) at keeping paroxysmal nocturnal hemoglobinuria (PNH) under control, a real-world case series shows. “Our real-world data reflect routine clinical practice, supporting the notion that [Ultomiris] may provide enhanced disease stability in high-risk patients,” researchers wrote. The results were…

High satisfaction reported with Fabhalta in PNH patient interviews

Most people with paroxysmal nocturnal hemoglobinuria (PNH) treated with Fabhalta (iptacopan) in clinical trials reported high satisfaction and a meaningful easing of symptoms with the oral therapy, and generally preferred it over other older treatments. In fact, all patients previously treated with the PNH therapies Soliris (eculizumab)…

Novartis, Atropos to use AI to find undiagnosed PNH patients

Atropos Health will partner with Novartis to develop artificial intelligence (AI) models to help identify people with rare diseases, such as paroxysmal nocturnal hemoglobinuria (PNH), who haven’t yet been diagnosed. Using AI algorithms trained on real-world data, the collaboration seeks to reduce the time from the onset…

Money, logistics add to treatment burden for PNH patients in Japan

In interviews, people in Japan with paroxysmal nocturnal hemoglobinuria (PNH) reported financial and logistical concerns — primarily, losing time from work and spending hours waiting for examinations and infusions — that increased the treatment burden they face in living with PNH. Patients also shared with researchers their worries about…

Most PNH patients on Empaveli avoid blood transfusions

Over the course of up to three years of treatment with Empaveli (pegcetacoplan), most people with paroxysmal nocturnal hemoglobinuria (PNH) did not require blood transfusions, according to a new analysis of clinical trial data. The analysis also indicated Empaveli led to long-term easing of fatigue and reductions in…

PNH linked to thrombosis, kidney failure in Nordic study

About one in five patients newly diagnosed with paroxysmal nocturnal hemoglobinuria (PNH) in the Nordic countries has a history of blood clots obstructing blood vessels — known as thrombosis — or develops kidney failure, a study in Denmark, Finland, Norway, and Sweden found. “The high number of thromboses and…

Complement inhibitor HRS-5965 safe, effective in PNH patients

Treatment with HRS-5965, a complement inhibitor being developed by Jiangsu Hengrui Pharmaceuticals, increased the levels of hemoglobin and reduced red blood cell destruction in people with paroxysmal nocturnal hemoglobinuria (PNH), according to data from a clinical trial. Data from the Phase 2 trial (NCT06051357), which assessed the…