In a woman with paroxysmal nocturnal hemoglobinuria (PNH) who developed acute kidney damage and low numbers of red blood cells and platelets during a COVID-19 infection, doctors suspected another disease called complement-mediated thrombotic microangiopathy (TMA). Her condition rapidly improved after treatment with Soliris (eculizumab). “Viral insults can serve…
Discussion
Seven people with paroxysmal nocturnal hemoglobinuria (PNH) in Kenya went months to years before receiving a diagnosis, according to a case series highlighting the challenges of recognizing and treating the rare, acquired blood disorder in resource-limited settings. All seven had recurrent anemia, or a shortage of healthy red blood…
Discussion
Anemia, or a shortage of healthy red blood cells, may have a greater impact on quality of life than ongoing red blood cell destruction — the hallmark of paroxysmal nocturnal hemoglobinuria (PNH) — despite treatment in people with the rare acquired disease, a real-world study suggests. Individuals with significant…
Discussion
Last in a series. Read part one. In my last column, I discussed when it might be time to consider a bone marrow transplant for paroxysmal nocturnal hemoglobinuria (PNH). But considering it and actually deciding to move forward are two very different things. If that conversation ever becomes…
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